The examples assume the path to your project's docroot directory is /home/hpotter/pykwiki/MyBlog/docroot/

SimpleHTTPServer

$ cd /home/hpotter/pykwiki/MyBlog/docroot
$ python -m SimpleHTTPServer
Serving HTTP on 0.0.0.0 port 8000 ...

Apache

<VirtualHost *:80>
    ServerName www.myblog.com
    DocumentRoot "/home/hpotter/pykwiki/MyBlog/docroot/"
    ErrorDocument 404 /404.html
    <Directory "/home/hpotter/pykwiki/MyBlog/docroot/">
        RewriteEngine Off
        Options Indexes FollowSymLinks MultiViews
        AllowOverride None
        Order allow,deny
        allow from all
    </Directory>
</VirtualHost>